CR contraindications
This page is intended to list pathologies where calorie
restriction can be counter-productive.
Influenza
Influenza and calorie restriction don't work well together.
This is unfortunate - since influenza causes irregular
worldwide pandemics that have historically killed
a significant fraction of the human race.
Malnutrition and energy restriction differentially affect viral immunity.
Caloric restriction decreases survival of aged mice in response to primary influenza infection.
Amyotrophic Lateral Sclerosis
A.L.S. and calorie restriction may not go together well either.
Caloric restriction transiently improves motor performance but hastens clinical onset of disease in the Cu/Zn-superoxide dismutase mutant G93A mouse.
No benefit of dietary restriction on disease onset or progression in amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase mutant mice.
The metabolic hypothesis in amyotrophic lateral sclerosis: insights from mutant Cu/Zn-superoxide dismutase mice.
Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model.
Hypermetabolism in ALS: Correlations with Clinical and Paraclinical Parameters.
Factors correlated with hypermetabolism in patients with amyotrophic lateral sclerosis.
Nutritional status of patients with amyotrophic lateral sclerosis: relation to the proximity of death.
Nutritional considerations in the management of patients with amyotrophic lateral sclerosis (ALS).
Mitochondria in Amyotrophic Lateral Sclerosis: A Trigger and a Target.
Mitochondrial dysfunction and its role in motor neuron degeneration in ALS.
Sporadic amyotrophic lateral sclerosis as an infectious disease: A possible role of cyanobacteria?
Papers relating to the relevance of the SOD mouse model to
Sporadic Amyotrophic Lateral Sclerosis patients:
Transgenic mouse models of amyotrophic lateral sclerosis.
Nutritional considerations in the management of patients with amyotrophic lateral sclerosis (ALS).
Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis.
Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis.
Metabolic dysfunction in familial, but not sporadic, amyotrophic lateral sclerosis.
Note that the last paper suggests that the S.O.D. metabolic
dysfunction may be confined to the 10% of A.L.S.
population which have the disease for genetic reasons.
This is the model used in all the earlier rodent papers -
that concluded that CR was unhelpful.
Smoking
Calorie restriction seems to make smokers smoke more.
For those more at risk from smoking than obesity, giving up the
fags first may be recommended.
Calorie restriction increases cigarette use in adult smokers.
Cancer
Calorie restriction generally has a positive effect on
cancer - but sometimes feeding those with existing
cancers is part of the recommended therapy.
Eating disorders
CR may be like playing with fire for those with a history of
anorexia nervosa, bulimia nervosa or binge eating
disorders.
Old age
For a variety of reasons, many organisms get thin before
they die. If you are already on this section of the road,
it seems quite possible that calorie restriction will hasten
your demise.
Disclaimer
The information on these pages is intended for educational
use only. Practitioners are recommended to consult with
a qualified medical advisor before making any dietary
changes.
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